Non-Invasive Assessment of the Spatial and Temporal Distributions of Interstitial Fluid Pressure, Fluid Velocity and Fluid Flow in Cancers <i>In Vivo</i>

Interstitial fluid pressure, interstitial velocity and related parameters are of great clinical significance for cancer diagnosis, prognosis treatment. A limited number non-invasive techniques can be used to estimate these mechanopathological in cancers vivo. In this study, we designed tested new ultrasound poroelastography methods capable estimating the magnitude spatial distribution flow inside tumors under external compression. We theoretically proved that estimated using from a tumor creep compression directly underlying flow, respectively, differing only peak values. Furthermore, by knowledge pressure poroelastography, it is possible derive: parameter ?, which quantifies vascular permeability ratio effective tumor. Our were validated finite element simulations variety simulated phantoms. Excellent qualitative agreement was found between obtained models corresponding proposed models. The ? differ theoretical value less than 10%. Experiments on human breast animal model as proof-of-principle feasibility